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O: Fachverband Oberflächenphysik
O 32: Poster Session - Organic Molecules on Inorganic Substrates: Adsorption and Growth
O 32.5: Poster
Montag, 16. März 2020, 18:15–20:00, P1C
Adsorption of miRNA molecules on metal surfaces studied by STM — •Miriam Meyer1,2, Christophe Nacci1, Grant J. Simpson1, Oliver Werzer2, Andreas Zimmer2, and Leonhard Grill1 — 1Institute of Chemistry, University of Graz, Austria — 2Institute of Pharmaceutical Sciences, University of Graz, Austria
In solution, microRNAs and protamine spontaneously form nanoparticles, which are auspicious candidates for the treatment of various diseases [1]. This self-assembly process is induced by strong electrostatic interactions. To deliberately modify this interplay, accurate knowledge of the molecular interactions at the single molecule level is desired. The deposition of microRNA molecules onto a metallic surface is done via electrospray ion beam deposition (ES-IBD). This method allows for the clean and intact transfer of large molecules onto a surface in ultrahigh vacuum (UHV) [2]. The adsorption geometry of microRNA is dependent on the kinetic energy with which it impinges on the surface. We have then investigated the adsorption of these molecules on metallic substrates by scanning tunneling microscopy (STM). The adsorption is compared for different preparation techniques, ES-IBD and drop-casting.
Acknowledgements: The financial support from the Doctoral Academy NanoGraz is highly acknowledged by the Grill and the Zimmer group.
[1] M. Junghans, J. Kreuter, and A. Zimmer, Nucleic Acids Res 28, 10 (2000). [2] Z. Deng, N. Thontasen, N. Malinowski, G. Rinke, L. Harnau, S. Rauschenbach, and K. Kern, Nano Lett 12, 5 (2012)