BPCPPDYSOE21 – scientific programme
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BP: Fachverband Biologische Physik
BP 21: Systems Biology III
BP 21.3: Talk
Tuesday, March 23, 2021, 14:50–15:10, BPa
Morphology of spherical epithelial monolayers — •Aboutaleb Amiri1, Charlie Duclut2,3, Carl Modes2,3, and Frank Jülicher1,3 — 1Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany — 2Max Plack Institute for Molecular Cell Biology and Genetics, 01037 Dresden, Germany — 3Center for Systems Biology Dresden, 01307 Dresden, Germany
We develop a generalised vertex model off the mechanics of epithelial cell monolayers to study morphogenesis in three dimensions. In this approach, a cell is represented by a polyhedron which is characterised by the location of its vertices in 3D space. We take into account apical, basal, and lateral cell surface tension, as well as pressure differences between outside and inside the cells. We consider an epithelium with spherical topology enclosing a lumen and investigate mechanisms that can generate different morphologies. In particular, we are interested in the roles of mechanical feedback on cell behaviours for the morphogenesis of closed epithelial monolayers.