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BP: Fachverband Biologische Physik
BP 23: Focus Biological Cells in Microfluidics II
BP 23.2: Vortrag
Dienstag, 23. März 2021, 14:20–14:40, BPc
Lingering dynamics of microvascular blood flow — •Alexander Kihm1, Stephan Quint1, Matthias Laschke2, Michael Menger2, Lars Kaestner1, Thomas John1, and Christian Wagner1 — 1Department of Experimental Physics, Saarland University, Saarbruecken, Germany — 2Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany
The microvascular networks in the body of vertebrates consist of the smallest vessels, such as arterioles, venules, and capillaries. The flow of red blood cells (RBCs) through these networks ensures the gas exchange in, as well as the transport of nutrients towards the tissues. Any alterations in this blood flow may have severe implications on the health state. Since the vessels in these networks obey dimensions similar to the diameter of RBCs, dynamic effects on the cellular scale play a key role. The steady progression in numerical modeling of RBCs even in complex networks has led to novel findings in the field of hemodynamics, especially concerning the impact and the dynamics of lingering events. However, these results are yet unmatched by a detailed analysis of the lingering in experiments in vivo. To quantify this lingering effect in in vivo experiments, we analyze branching vessels in the microvasculature of Syrian hamsters via intravital microscopy and the use of an implanted dorsal skinfold chamber. We present a detailed analysis of these lingering effects of cells at the apex of bifurcating vessels, affecting the temporal distribution of cell-free areas in the branches and even causing a partial blockage in severe cases.