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BP: Fachverband Biologische Physik

BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.

BP 24.21: Poster

Dienstag, 23. März 2021, 16:00–18:30, BPp

Optimal hematocrit for ATP release by red blood cell in microcirculation — •Zhe Gou and Chaouqi Misbah — Laboratoire Interdisciplinaire de Physique, Grenoble, France

ATP release by red blood cells (RBCs) acts as an important signaling molecule for various physiological functions, such as vasodilation. When flowing in microcirculation, RBCs experience a cascade of branching vessels, from arterioles to capillaries, and finally to venules, which affects not just flow behavior of blood but also ATP release. In a previous study, we have proposed a model of ATP release by RBCs through two pathways of cell membrane: pannexin 1 channel (Px1), sensitive to shear stress, and cystic fibrosis transmembrane conductance regulator (CFTR) which responds to cell deformation. As a continuation, present work further investigates the effect of flow strength, hematocrit, and vascular diameter by numerical simulations. We found a nontrivial spatial RBC organization and ATP patterns due to application of shear stress on the RBC suspension. Conditions for optimal ATP release per cell are identified, which depend on vessel size and hematocrit Ht. Increasing further Ht beyond optimum enhances the total ATP release but should degrade oxygen transport capacity, a compromise between an efficient ATP release and minimal blood dissipation. Moreover, ATP is boosted in capillaries suggesting a vasomotor activity coordination throughout the resistance network. Further studies of vascular network may help to explore the whole signaling cascade of ATP.