BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.
BP 24.28: Poster
Dienstag, 23. März 2021, 16:00–18:30, BPp
Extracellular matrix mechanical prestress during morphogenesis of Drosophila wing discs — •Yanín Guerra2, Elisabeth Fischer-Friederich2, and Christian Dahmann1 — 1Institute of Genetics, Technische Universität Dresden, 01062 Dresden, Germany. — 2Biotechnology Center of the TU Dresden (Biotec), Tatzberg 47/49, 01062 Dresden, Germany
The folding of tissues is the manner in which two dimensional sheets transform into three dimensional structures. There are many mechanisms involved in fold formation such as apical constriction, cell proliferation, collective migration and cell-ECM adhesion. For a long time it has been thought that the most important process is apical constriction, notwithstanding, how this mechanisms organise to construct healthy three dimensional structures remains as an open question.
A recent study on the mechanical processes involved during hinge fold formation of the Drosophila wing imaginal disc found that there is a decrease of basal tension in the central fold (H/H fold), but no apical constriction [1]. Moreover, they report that this fold exhibits a depletion of the extracellular matrix (ECM) suggesting that the dynamics of such structure drive fold formation. So, how does the interaction between the ECM and the actomyosin networks contributes to basal tension in the morphogenesis of the H/H fold in Drosophila wing disc?
The main goal of this research is to elucidate the role of ECM in the formation of H/H fold in Drosophila wing. To achieve this goal I will culture the wing imaginal discs ex vivo in order tomeasure its mechanical properties using atomic force microscopy.