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BP: Fachverband Biologische Physik

BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.

BP 24.32: Poster

Dienstag, 23. März 2021, 16:00–18:30, BPp

Dynamic analysis of the SinR/SlrR/SinI genetic circuit for biofilm formation in Bacillus subtilis — •Simon Dannenberg, Jonas Penning, and Stefan Klumpp — Institut für Dynamik komplexer Systeme Georg-August-Universität Göttingen Friedrich-Hund-Platz 1 37077 Göttingen, Germany

Switching between different lifestyles in bacteria serves as a survival strategy under changing environmental conditions. It allows genetically identical cells to develop different phenotypic traits and creates diversity in a colony of cells. Such switches either occur stochastically due to fluctuations in gene expression or are the result of a deterministic process. In our work we investigate biofilm formation by mathematical analysis of the SinR/SlrR/SinI genetic circuit in Bacillus subtilis. Via a rate equation approach for the involved proteins, steady state solutions are found in which parameter regions for bistability exists. For those regions we conducted a stochastic analysis using a Gillespie algorithm, which shows that typical fluctuations are not sufficient to induce the transitions between these states. Instead, we propose a deterministic switching mechanism and analyzed its dynamic.