BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.
BP 24.35: Poster
Dienstag, 23. März 2021, 16:00–18:30, BPp
Comparative analysis of metabolic and transcriptomic features of Nothobranchius furzeri — •Maria Rita Fumagalli1,2,3, Francesc Font-Clos1,4, Simone Milan1, Stefano Zapperi1,4,5, and Caterina A.M. La Porta1,2,3 — 1Center for Complexity and Biosystems, University of Milan — 2Biophysics Institute, CNR, Genova — 3Dep. of Environmental Science and Policy, University of Milan — 4Dep. of Physics, University of Milan — 5ICMATE, CNR, Milan
Nothobranchius furzeri is a killifish with an extremely rapid growth and short lifespan with respect to other vertebrates. Despite its short life, N. furzeri shows hallmarks typical of aging. We investigated the aging process of N. furzeri in comparison with other two well characterized animal models (Danio rerio and Mus Musculus) with a combination of computational analysis and modeling.
The analysis of gene expression changes during ageing suggests the presence of alterations in regulatory mechanisms happening early during N. furzeri lifetime. Coherently, N. furzeri shows a specific deregulation pattern of genes involved in chromatin remodeling as well as histone acetylation and deacetylation. Enzymes deregulation could affect metabolic reactions, but changes in terms of efficiency in the production/consumption of metabolites are not easy to address. To this end, we implemented a metabolic network model based on flux balance analysis applying it to the fundamental glycolysis pathway.
Overall, our analysis shows that N. furzeri ageing process is associated to very peculiar chromatin and metabolic dynamics.