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BP: Fachverband Biologische Physik
BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.
BP 24.36: Poster
Dienstag, 23. März 2021, 16:00–18:30, BPp
Dynamics of tethered polymers in a circular confinement — •Meng Wang1,2, Tim Klingberg1,2, Mauro Battipede1,2, Vasily Zaburdaev1,2, and Hui-Shun Kuan1,2 — 1Friedrich-Alexander-Universität Erlangen-Nürnberg — 2Max-Planck-Zentrum für Physik und Medizin
During meiosis, the paternal and maternal chromosomes find each other to pair and exchange parts of their genetic material in the process of recombination, which is the major mechanism contributing to genetic diversity in sexually reproducing organisms. As the first steppingstone in understanding how physical mechanisms help chromosomes to align, we study the dynamics of chromosomes in the nucleus. In this poster, we consider meiotic DNA as a freely jointed chain confined in a circle with the ends of the chain being tethered and free to move along the circle. We use the kinetic Monte Carlo algorithms to simulate the stochastic motion of the polymer and compare the results to the Rouse model. Although the Rouse model successfully describes the simulation results, especially the transient subdiffusive regimes, the global motion of the polymer is very different due to the constraint of the circle. For small monomer numbers, the polymer can stretch to match the diameter of the circle, and the trajectory of its each end can wind around the circle. However, with fixed polymer length, for large monomer numbers, the chain tends to form a contracted coil, stochastically moving along the circle like a composite particle in the long-time limit.