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BPCPPDYSOE21 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.

BP 24.37: Poster

Dienstag, 23. März 2021, 16:00–18:30, BPp

Dimensionality of neural circuit manifolds associated with a salt-and-pepper organization of cortical stimulus preferences — •Michael Sternbach1,2,3 and Fred Wolf1,2,3,4,51Campus Institute for Dynamics of Biological Networks, Göttingen, Germany — 2Max Planck Institute for Dynamics and Self-Organization — 3Bernstein Center for Computational Neuroscience Göttingen — 4Institute for Dynamics of Complex Systems, Georg-August University Göttinge — 5Max Planck Institute of Experimental Medicine

Biological neural circuits are expected to converge to one of many stable network configurations. For the form vision core circuit of primate/carnivore V1 prior work indicates that stable network configurations form toroid high-dimensional continua (Wolf 2005, Kaschube et al. 2010). Similar results for network configurations in rodents V1, called salt-and-pepper organizations (SaP), are currently not available. Here we utilize techniques from the study of spin liquid states (Chalker 2015) to construct mathematically tractable models with SaP optimal states. We demonstrate that these models can exhibit ground state manifolds with extensive dimensionality. This result is consistent with the general expectation that there are a very high number of equivalent SaP configurations. These studies expand the toolbox for analyzing the multiplicity of stable cortical circuit configurations. Our first results suggest that the evolutionary transition from a rodent ancestral circuit configurations of V1 to a primate/carnivore V1 architecture was accompanied by a reduction in cortical circuit state dimension.

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