BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.
BP 24.38: Poster
Dienstag, 23. März 2021, 16:00–18:30, BPp
Trading bits in the readout from a genetic network — •Marianne Bauer1, Mariela Petkova2, Thomas Gregor1,3, Eric Wieschaus1, and William Bialek1,4 — 1Princeton University, Princeton, USA — 2Harvard University, Boston, USA — 3Institut Pasteur, Paris, France — 4City University of New York, New York, USA
In genetic networks, information of relevance to the organism is represented by the concentrations of transcription factor molecules. In order to extract this information the cell must effectively "measure" these concentrations, but there are physical limits to the precision of these measurements. We explore this trading between bits of precision in measuring concentration and bits of relevant information that can be extracted, using the gap gene network in the early fly embryo as an example. We argue that cells in the embryo can extract all the available information about their position, but only if the concentration measurements approach the physical limits to information capacity. These limits necessitate the observed proliferation of enhancer elements with sensitivities to combinations of transcription factors, but fine tuning of the parameters of these multiple enhancers is not required.