BPCPPDYSOE21 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Poster B: Active Biological Matter, Cell Mechanics, Systems Biology, Computational Biophysics, etc.
BP 24.9: Poster
Dienstag, 23. März 2021, 16:00–18:30, BPp
Mechanochemical dynamics of spherical active surfaces subject to load-dependent cross-linkers — •Mirco Bonati1,2, Lucas Wittwer3, Elisabeth Fischer-Friedrich1,2, and Sebastian Aland4 — 1Fischer-Friedrich Lab, Biotechnologisches Zentrum, Technische Universitat Dresden, Dresden, Germany. — 2DFG Excellence Cluster Physics of Life — 3HTW Dresden, Friedrich-List-Platz 1, 01069 Dresden, Germany — 4TU Bergakademie Freiberg, Akademiestrasse 6, 09599 Freiberg, Germany
Mechanochemical dynamics of active surfaces, as the thin cellular actin cortex, play a crucial role in several biological processes such as cell shape regulation and morphogenesis. Relying on a hydrodynamic theory of curved active surfaces and elastic thin shell theory, we aim to study both theoretical and numerical aspects of the self-organized pattern formation of the cell cortex. Our goal is to develop a mathematical model that takes into accounts biologically relevant facts, such as load-dependence of molecular unbinding and cortical strain stiffening. In particular, we want to study the influence of catch and slip bond cross-linkers on active gel pattern formation as it has been shown that the mechanical stiffness of the actin cytoskeleton can vary greatly with small changes in cross-linkers concentration. This force-sensing may give rise to new aspects of pattern formation.