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BP: Fachverband Biologische Physik

BP 8: Bioimaging and Biospectroscopy

BP 8.6: Vortrag

Montag, 22. März 2021, 15:40–16:00, BPb

A multisensory interface for exploring nanomechanical tissue properties with human senses — •Robert Magerle, Paul Zech, Martin Dehnert, Alexandra Bendixen, and Andreas Otto — Fakultät für Naturwissenschaften, TU Chemnitz

Tissues display a complex spatial structure and their mechanical properties remain largely unexplored on the nanometer scale. Here we present a multisensory interface that makes nanomechanical tissue properties accessible to human perception and cognition. With a haptic device, we translate the 3D force fields measured with an atomic force microscope (AFM) on the nanometer scale into forces perceivable to humans. This allows human users to explore haptically the specimen's surface shape as well as its local nanomechanical properties while simultaneously employing multiple senses. First tissues studied include native (unfixed), hydrated tendon of sheep, chickens, and mice. AFM imaging in air with controlled humidity preserves the tissue's water content and allows for high-resolution imaging. The force-vs.-distance (FD) data measured with the AFM display a rate-independent hysteresis with return-point memory. A generic hysteresis model that uses FD data collected during one approach-retract cycle predicts the force (output) for an arbitrary indentation trajectory (input). We implemented this hysteresis model with a haptic device which allows human users to perceive a physically plausible tip--sample interaction. They can discriminate the specimen's local hardness, its elastic response, as well as the energy dissipation due to the rate-independent hysteretic process.