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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 11: Active Matter 2 - organized by Carsten Beta (Potsdam), Andreas Menzel (Magdeburg) and Holger Stark (Berlin) (joint session DY/BP/CPP)
CPP 11.2: Talk
Tuesday, March 23, 2021, 11:20–11:40, DYa
Rewarding cargo-carrier interactions: cell-mediated particle transport — •Valentino Lepro1,2, Robert Großmann1, Oliver Nagel1, Stefan Klumpp3, Reinhard Lipowsky2, and Carsten Beta1 — 1Institute of Physics and Astronomy, University of Potsdam, 14476 Potsdam, Germany — 2Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany — 3Institute for the Dynamics of Complex Systems, University of Göttingen, 37077 Göttingen, Germany
As society paves its way towards devices miniaturization and precision medicine, micro-scale actuation and guided transport become increasingly prominent research fields, with high potential impact in both technological and clinical contexts. To accomplish directed motion of micron-sized cargos towards specific target sites, a promising strategy is the usage of living cells as smart biochemically-powered carriers, developing so-called bio-hybrid systems. In this talk, we discuss eukaryotic active particle transport, using Dictyostelium discoideum as a model organism. We shed light on the underlying mechanics and the emerging dynamics governing such cell-mediated transport. A simple yet powerful model is proposed which reproduces the observed phenomenology and, moreover, elucidates the role of cell-cargo interactions for the long-time mass transport efficiency.