BPCPPDYSOE21 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 12: Focus Phase Separation in Biological Systems II (joint session BP/CPP)

CPP 12.1: Vortrag

Dienstag, 23. März 2021, 14:00–14:20, BPb

Phase separation provides a mechanism to reduce noise in cells — •Florian Oltsch^1,2, Adam Klosin¹, Tyler Harmon^1,3, Alf Honigmann^1,4, Frank Jülicher^2,3,4, Anthony Hyman^1,2,4, and Christoph Zechner^1,2,4 — ¹Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany — ²Center for Systems Biology Dresden, 01307 Dresden, Germany — ³Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany — ⁴Cluster of Excellence Physics of Life, TU Dresden, 01062 Dresden, Germany

Noise in gene expression can cause significant variability in protein concentration. How cells buffer variation in protein concentration is an important question in biology. In this talk, I will show that liquid-liquid phase separation provides an effective mechanism to reduce variability in protein concentration. First, I will introduce our theoretical framework that discusses phase separation in the presence of active protein production and turnover. This stochastic non-equilibrium model allows us to study how fluctuations in protein concentration are affected by phase separation. I will then present under which physical conditions noise buffering by phase separation can be effective. Subsequently, I will show experimental data to test our theoretical predictions.