BPCPPDYSOE21 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 13: Complex Fluids and Soft Matter 3 (joint session DY/CPP)
CPP 13.2: Vortrag
Dienstag, 23. März 2021, 14:50–15:10, DYc
Hydraulic and electric control of cell spheroids — •Charlie Duclut1, Jacques Prost2, and Frank Jülicher1,3 — 1Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2Laboratoire Physico Chimie Curie, Institut Curie, Paris, France — 3Center for Systems Biology Dresden, Germany
In addition to generating forces and reacting to mechanical cues, tissues are capable to actively pump fluid and create electric current. In this talk, we will discuss how a hydraulic or electrical perturbation, imposed for instance by a drain of micrometric diameter, can be used to perturb tissue growth dynamics. We address this issue in a continuum description of a spherical cell assembly that includes the mechanical, electrical and hydraulic properties of the tissue. This approach allows us to discuss and quantify the effect of electrohydraulic perturbations on the long-time states of the tissue. We highlight that a sufficiently strong external flow or electric current can drive a proliferating spheroid to decay. We propose that this could have applications in medicine.