SKM 2021 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 15: Theory and Simulation (joint session CPP/DY)

CPP 15.2: Talk

Friday, October 1, 2021, 14:00–14:15, H3

Are there knots in chromatin? — •Peter Virnau — Institut für Physik, Staudingerweg 9, Johannes Gutenberg-Universität Mainz, 55128 Mainz

The rise of HiC chromosome capture methods has recently enabled low-resolution structures of interphase chromatin [1]. In this presentation I will explain how structures based on single cell contact matrices are obtained from simulations of coarse-grained bead-spring polymer Go models [2]. The role of self-entanglements which naturally occur in this process [2,3] will be critically assessed in the light of theoretical arguments and recent experiments [4].

[1] T.J. Stevens et al, Nature 544, 59-64 (2017). [2] S. Wettermann et al, Comp. Mat. Sci 173, 109178 (2020). [3] J.T. Siebert et al, Polymers 9, 317 (2017). [4] D. Goundaroulis, Biophys. J. 118, 2268-2279 (2020).