SKM 2021 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 8: Poster Session III

CPP 8.6: Poster

Wednesday, September 29, 2021, 17:30–19:30, P

Protein-polysaccharide nanoparticles stabilized by thermal treatment — •Johannes Allwang¹, Yanan Li¹, Stefano Da Vela², Dimitris Selianitis³, Angeliki Chroni³, Aristeidis Papagiannopoulos³, and Christine M. Papadakis¹ — ¹Physics Department, Technica University Munich, Garching, Germany — ²EMBL, DESY, Hamburg, Germany — ³Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, Greece

Protein complexes appear in healthy and diseased life forms as well as in food systems and medical applications. Their study can, therefore, give vital insights into biological mechanisms and help understand and treat diseases. Thermal treatment of protein-polysaccharide complexes was shown to create tunable nanoparticles with potential applications as carriers for nutriens and drugs [1].

Here, we investigate nanoparticles from trypsin; a proteolytic enzyme from the small intestine [2]. We use two different polysaccharides: hyaluronic acid and chondroitin sulfate. Synchrotron small-angle x-ray scattering is combined with light scattering methods to get insight into both the internal structure of the particles and their overall size.

[1] A. Papagiannopoulos, E. Vlassi, A. Radulescu, Carbohydr. Polym. 2019, 218, 218

[2] S. Trampari, A. Papagiannopoulos, S. Pispas, Biochem. Biophys. Res. Commun. 2019, 515, 282