SKM 2021 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 10: Focus session: Nonlinear Dynamics of the Heart I (organized by Markus Bär, Stefan Luther and Ulrich Parlitz)
DY 10.1: Hauptvortrag
Mittwoch, 29. September 2021, 15:00–15:30, H6
Effect of fibrosis on propagation on non-linear waves and onset of arrhythmias in cardiac tissue — •Alexander Panfilov1,2, Timur Nezlobinsky1,2, and Farhad Pashakhanloo3 — 1Department of Physics and Astronomy, Ghent Unibversity, Belgium — 2Ural Federal University, Ekaterinburg, Russia — 3Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02115, USA
Cardiac fibrosis is a well-known arrhythmogenic condition which can lead to sudden cardiac death. Physically, fibrosis can be viewed as a large number of small obstacles in an excitable medium, which may create nonlinear wave turbulence or reentry. The relation between the specific texture of fibrosis and the onset of reentry is of great theoretical and practical importance. In my talk I present results of several recent studies which show how basic properties of wave propagation are affected by fibrosis. We also characterize properties of fibrotic texture which led to cardiac arrhythmias and propose a concept of minimal functional cluster which allows quantitatively predict the arrhythmia probability for different fibrosis densities and tissue excitabilities.