SKM 2021 – scientific programme

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SYHN: Symposium Hybrid Nanomaterials: From Novel Physics and Multi-Scale Self-Organization to Functional Diversity on the Device Scale

SYHN 1: Hybrid Nanomaterials: From Novel Physics and Multi-Scale Self-Organization to Functional Diversity on the Device Scale

SYHN 1.3: Invited Talk

Thursday, September 30, 2021, 11:15–11:45, Audimax 1

Multivalent nanoparticles for targeted binding — •Stefano Angioletti-Uberti — Department of Materials, Imperial College London, United Kingdom

Ligand-coated nanoparticles are a leading candidate for various applications where targeted binding is necessary, e.g. drug-delivery or biosensing, to name just two.
In this system, the main idea is that binding to the target occurs via the formation of ligand-receptor bonds. In fact, typically many of such bonds will form and in various competing patterns that vary not only depending on the bond strength but also on features such as grafting densities, or the geometry of binding. This results in highly tuneable binding affinities and more generally peculiar (and not yet fully exploited) novel binding properties that arise from the statistical nature of the binding, properties that could be exploited to achieve new functionalities.
In this talk, I will present some of our recent work to understand these so-called multivalent nanoparticles, showing how theory and simulations have been used to both rationalise and predict the behaviour of experiments and point the consequences of our findings for the development of nanomedicine applications based on multivalent binding.