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O: Fachverband Oberflächenphysik
O 16: Mini-Symposium: Free-standing functional molecular 2D materials II
O 16.5: Talk
Monday, March 1, 2021, 15:00–15:15, R2
Sensitive detection of biomarkers in clinical samples based on van der Waals heterostructures of carbon nanomembrane and graphene — •David Kaiser1, Nikolaus Meyerbroeker2, Werner Purschke3, Simone Sell3, Christof Neumann1, Andreas Winter1, Zian Tang1, Daniel Hüger1, Gerben Ferwerda4, Thomas Weimann5, Marien de Jonge4, Albert Schnieders2, Axel Vater3, and Andrey Turchanin1 — 1Friedrich Schiller University Jena, Germany — 2CNM Technologies GmbH, Germany — 3APTARION biotech AG, Germany — 4Radboud University, The Netherlands — 5Physikalisch-Technische Bundesanstalt, Germany
Due to their low surface charge in aqueous electrolytes, almost direct contact with the analyte and special electronic properties, graphene field-effect transistors (GFETs) are promising for ultrasensitive biodetection. However, challenges with their reliable biochemical functionalization have hindered their use with real clinical samples so far. Here, we employ 1 nm thick carbon nanomembranes (CNMs) to functionalize GFETs via van der Waals assembly of the CNM/graphene heterostructures. The aptamers grafted on the CNMs result in specific adsorption of the relevant biomarkes on the GFET surface. Using clinical samples, we demonstrate the detection of the biomarker CXCL8 with a very low concentration (5 pg/ml). We support our experimental findings by a detailed modelling of the device performance.