Erlangen 2022 – scientific programme

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MS: Fachverband Massenspektrometrie

MS 2: Mass Spectrometry Methods

MS 2.4: Talk

Monday, March 14, 2022, 17:30–17:45, MS-H9

Dissociative electron attachment studies with nitro-heterocyclic aromatic compounds — •Muhammad Saqib, Eugene Arthur-Baidoo, Milan Ončák, and Stephan Denifl — Institute of Ion Physics and Applied Physics, University of Innsbruck, Technikerstraße 25, 6020 Innsbruck, Austria

Nitro-heterocyclic aromatic compounds have a wide range of applications in medicine. Due to their specific toxicity, which is defined by their reduction to the biologically active form in the lack of oxygen, these compounds play a crucial role in targeting the hypoxic tumor cell during cancer treatment. We have studied the formation of anions following electron attachment to nitro-heterocyclic compounds in the gas phase. By using a crossed electron/molecular beams experiments with mass spectrometric detection of the anions, we studied electron attachment to 2-nitrofuran, 3-nitro-1,2,4-triazole, and 1H-1,2,4-triazole molecules. Dissociative electron attachment and non-dissociative electron attachment were observed. The obtained results of electron attachment to 2-nitrofuran indicate that low-energy electrons, with kinetic energies from 0 eV to 12 eV, effectively decompose the molecule and lead to a large variety of charged fragments and radicals with the nitrogen dioxide anion as the most abundant fragment anion. The experimental study was supported by thermochemical threshold calculations. This work was supported by the FWF, Vienna (P30332).