Erlangen 2022 – wissenschaftliches Programm

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Q: Fachverband Quantenoptik und Photonik

Q 43: Quantum Technologies

Q 43.1: Poster

Mittwoch, 16. März 2022, 16:30–18:30, P

Quantum Imaging of Living Tissues with Magnetic Nanoparticles — •Andre Pointner and Roland Nagy — LEB, FAU Erlangen-Nuremberg, Erlangen, Germany

The fight against cancer is one of the greatest challenges for clinicians, oncologists and researchers in this century. The main goal of cancer therapy is to prevent the tumor cell dissemination. Unfortunately, detecting the movement of individual cancer cells in vivo and in real time over an extended period of time has not been achieved so far. A promising solution to the aforementioned problem is the research field of quantum sensing. Quantum sensors such as the NV-Center in diamond are very well established and ready to be applied in the field of biology. We intend to use the outstanding properties of the NV center in diamond as a quantum magnetic field sensor to characterize the invasion potential of cancer cells and to describe how their interaction with immune cells triggers or inhibits proliferation. Therefore, we will selectively attach superparamagnetic iron oxide nanoparticles (SPIONs) to live cancer cells in tissues (200 µm thickness) contained in a life-sustaining incubator. The vector magnetic field generated by the SPIONs is measured by evaluating the spin hamiltonians along the four crystallographic [111] directions through NV centers. We will use optically detected continuous magnetic resonance (CW-ODMR) to measure the magnetic field with a wide-field microscope. A sequence of these measurements will result in magnetic vector images. The overlap of these images will accurately determine the migration of individual cancer cells in the tissue samples.