Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 10: Cell Adhesion and Multicellular Systems
BP 10.1: Vortrag
Dienstag, 6. September 2022, 10:00–10:15, H13
Physics of gut motility governs digestion and bacterial growth — •Agnese Codutti1,2, Jonas Cremer3, and Karen Alim1,2 — 1Physics Department and CPA, Technische Universität München — 2Max-Planck-Institut für Dyanmik und Selbstorgansiation, Göttingen — 3Stanford University
Malfunctioning of the small intestine contractility and the ensuing bacterial population therein are linked to a plethora of diseases. We, here, study how the small intestine’s variety of contractility patterns impacts nutrient uptake and bacterial population. Our analytical derivations in agreement with simulations identify flow velocity as the key control parameter of the nutrients uptake efficiency and bacterial growth, independently of the specifics of contractility patterns. Self-regulating flow velocity in response to the number of nutrients and bacteria in the gut allows achieving 100% efficiency in nutrient uptake. Instead of the specifics of intestine contractility, our work points to the flow velocity and its variation in time within the intestine to prevent malfunctioning.