Regensburg 2022 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Cell Adhesion and Multicellular Systems

BP 10.6: Vortrag

Dienstag, 6. September 2022, 11:30–11:45, H13

Model-Based Prediction of an Effective Adhesion Parameter Guiding Multi-Type Cell Segregation — •Philipp Rossbach, Hans-Joachim Böhme, Steffen Lange, and Anja Voss-Böhme — DataMedAssist, HTW - University of Applied Sciences, 01062 Dresden, Germany

The process of cell-sorting is essential for development and maintenance of tissues. With the Differential Adhesion Hypothesis, Steinberg proposed that cellsorting is determined by quantitative differences in cell-type-specific intercellular adhesion strengths. An implementation of the Differential Adhesion Hypothesis is the Differential Migration Model by Voss-Böhme and Deutsch. There, an effective adhesion parameter was derived analytically for systems with two cell types, which predicts the asymptotic sorting pattern. However, the existence and form of such a parameter for more than two cell types is unclear. Here, we generalize analytically the concept of an effective adhesion parameter to three and more cell types and demonstrate its existence numerically for three cell types based on in silico time-series data that is produced by a cellular-automaton implementation of the Differential Migration Model. Additionally, we classify the segregation behavior using statistical learning methods and show that the estimated effective adhesion parameter for three cell types matches our analytical prediction. Finally, we demonstrate that the effective adhesion parameter can resolve a recent dispute about the impact of interfacial adhesion, cortical tension and heterotypic repulsion on cell segregation.