Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 12: Poster 2
BP 12.35: Poster
Dienstag, 6. September 2022, 17:30–19:30, P4
Lattice based model to study wound healing in biofilms — •Yusong Ye1, Mnar Ghrayeb2, Liraz Chai2, and Vasily Zaburdaev1 — 1Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) & Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany — 2Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
Biofilms are multicellular heterogeneous bacterial communities excelling in social-like cooperation, division of labor, and resource capture. Bacteria in biofilms are embedded in the self-produced extracellular matrix (ECM). Increasingly more often an analogy between biofilms and higher multicellular organisms is drawn. One illustrative example is the process of wound healing. While it is extensively studied in eukaryotic tissues, the mechanisms of wound healing in biofilms are barely understood. The wound healing in biofilm is a regulated growth by which bacteria alter their physiological state in response to a damage. Motivated by experiments in a model biofilm forming bacteria Bacillus subtilis, we developed a lattice based model of a biofilm growth. It explicitly considers cells and ECM produced by cells, as well as nutrient fluxes and helps to elucidate the role of biofilm components (matrix, cells), aging, and nutrient availability in damage repair. Division of labor (growth vs. ECM production) and nutrient consumption play key roles in heterogeneous wound closure. Even under most general assumptions, the model qualitatively reproduces the wound healing phenotypes observed in our experiments and can be further generalised to include signalling and regulatory mechanisms.