Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 12: Poster 2
BP 12.37: Poster
Dienstag, 6. September 2022, 17:30–19:30, P4
Cancer tissue dynamics as active liquids — •Mahboubeh Farajian1, Swetha Raghuraman2, Alejandro Jurado Jimenez1, Fatemeh Abbasi1, and Timo Betz1 — 1Third Institute of Physics - Biophysics Georg August University Göttingen — 2Institute for Cell biology ZMBE - University of Münster
Collective cell migration can be found in some key biological processes such as Metastasis, wound healing and tissue rearrangement. While the molecular mechanisms of collective migration already represent a strong research focus, the mechanical processes driving it are currently less studied. Here we propose to answer this question: "Can statistical mechanics explain the local and global characteristics of cell migration in the tumors?" Someone can imagine 3 kinds of phenotypes regarding the collective cell migration: "Sub-diffusive", "Diffusive" and "Super-diffusive" motion. We aim to change the physical parameters of the environment such as Volume (by letting the tumor models grow) and Pressure (by addition of Dextran to the environment), and then look at the statistical mechanics of the cells' collective motion, different phenotypes and the transition between different phenotypes. and we use 3D individual cell tracks for this aim.