Regensburg 2022 – scientific programme

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BP: Fachverband Biologische Physik

BP 12: Poster 2

BP 12.39: Poster

Tuesday, September 6, 2022, 17:30–19:30, P4

3D Force Model of early zebrafish development via NeuralODEs — •Leon Lettermann, Sebastian Herzog, Alejandro Jurado, Florentin Wörgötter, and Timo Betz — 3rd Institute of Physics - Biophysics, University of Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen

The astonishing process of embryo development still poses a great variety of unanswered questions today. Motivated by the importance of understanding cell migration and organization patterns, we want to study the movements in the early development of zebrafish embryos on a mesoscopic scale. A coarse-grained tissue flow obtained from light sheet microscopy data is analyzed based on a hydrodynamic model. This model is enhanced by active stresses and forces, redirecting the flow away from a dead liquid's description. Using a Neural Ordinary Differential Equation, the active contributions can be reconstructed from observations, shedding light on the distribution of active forces and stresses in the embryo. This allows for quantifying symmetry breaking due to active effects and early recognition of the forming body axes.