Regensburg 2022 – scientific programme
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BP: Fachverband Biologische Physik
BP 12: Poster 2
BP 12.42: Poster
Tuesday, September 6, 2022, 17:30–19:30, P4
Investigation of the binding behaviour of proteins in various patterns — •Jonas Walther1 and Ana-Sunčana Smith1,2 — 1PULS Group, Department of Physics, Interdisciplinary Center for Nanostructured Films, Friedrich-Alexander-Universität Erlangen-Nürnberg, Cauerstraße 3, 91058 Erlangen, Germany — 2Group for Computational Life Sciences, Ruđer Bošković Institute, Zagreb, Croatia
The coupling of two or more cellular membranes is an important part of cell interactions and therefore affects many biological mechanisms. Cells may restrict the movement of proteins in certain areas of their membrane creating functionally specialized regions, or membrane domains. Here we analyse whether the arrangement of proteins in different patterns changes the binding kinetics of the proteins. In our investigation we combine kinetic Monte Carlo simulations and explicit calculations of the binding rates of the patterns. Results show that there is indeed a difference in binding of the different patterns. An important factor seems to be the amount of proteins within a pattern due to the correlations between the proteins. The exact difference of the binding rates depends on the mechanical properties of the membrane and the proteins. We furthermore analyse the dynamics of bond formation and compare the results to experimental data on the activation of natural-killer cells binding to analogous patterns (experiment by the group of Mark Schvartzman at the Ben-Gurion Univeristy of the Negev).