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BP: Fachverband Biologische Physik

BP 12: Poster 2

BP 12.52: Poster

Dienstag, 6. September 2022, 17:30–19:30, P4

The effect of additives on the lamellar-to-cubic transition dynamics of monoolein at excess water conditions — •Jaqueline Savelkouls, Michelle Dargasz, Göran Surmeier, and Michael Paulus — Fakultät Physik/DELTA, Technische Universität Dortmund, 44221 Dortmund, Germany

Monoolein is an amphiphilic lipid, which is of particular interest in the pharmaceutical industry. Monoolein swells in excess water and forms several lyotropic liquid crystalline structures. In the cubic Pn3m phase, monoolein can release a previously added drug by slow diffusion in the human body [1]. Measurements are performed at the beamline BL2 of the synchrotron radiation source DELTA (Dortmund, Germany) using the small angle X-ray scattering (SAXS) set-up to study the pressure-induced transition from the lamellar crystalline phase to the cubic Pn3m phase. 20 wt% monoolein was mixed in water with salts or drugs. Diffraction patterns are recorded, from which the lattice constants for each phase can be determined. The results show that a much larger lattice constant of the Pn3m phase is formed after the pressure jump compared to the equilibrium state before the pressure increase. Given some time, the system relaxes, causing the lattice constant to approach the equilibrium lattice constant. The rate of relaxation depends on the added additives. In summary, the formation of the liquid crystalline phases of monoolein allows drugs to be released over a long period of time. The speed of diffusion can be optimized by the addition of salts.

[1] Adriana Ganem-Quintanar, "Monoolein: A Review of the Pharmaceutical Applications", p.813 (2000)