Regensburg 2022 – scientific programme
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BP: Fachverband Biologische Physik
BP 12: Poster 2
BP 12.57: Poster
Tuesday, September 6, 2022, 17:30–19:30, P4
Spatial-Stochastic Model of Cell Fate Decisions in Early Mouse Development — •Michael Alexander Ramirez Sierra1, Tim Liebisch1,2, Sabine C. Fischer3, Franziska Matthäus1,2, and Thomas R. Sokolowski1 — 1Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main, Germany — 2Goethe Universität Frankfurt am Main, Germany — 3Julius-Maximilians-Universität Würzburg, Germany
The delicate balance necessary for ensuring reliable specification of cell lineages is an intriguing problem in developmental biology. As an important paradigm in tissue development, the early mouse embryo cell fate decisions have been extensively researched, but the underlying mechanisms remain poorly understood. Current approaches to this problem still primarily rely on deterministic modeling techniques, although stochasticity is an inherent feature of this biological process. We are developing a multi-scale event-driven spatial-stochastic simulator for emerging-tissue development. We build up new simulation schemes for incorporating suitable tissue-scale phenomena, and we fix important parameters by using experimental values or numerical optimization to infer biophysically-feasible regimes. We first explore the characteristics of this system in a single-cell setting. We then extend the study to a multi-cellular setting in order to understand how positional information is robustly achieved and preserved. Our latest results indicate a potential signaling mechanism for reliable patterning emergence, despite strong constraints imposed by cell cycles. We are closely exploring how these signals redefine cell fates.