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BP: Fachverband Biologische Physik
BP 12: Poster 2
BP 12.65: Poster
Dienstag, 6. September 2022, 17:30–19:30, P4
Statistical modelling of cerebral blood flow and transport in microvascular networks — •Florian Goirand1, Tanguy Le Borgne2, and Lorthois Sylvie3 — 1Center for Protein Assemblies, Physics Department, Technische Universität München, Garching bei München, Germany — 2University of Rennes, CNRS, Géosciences Rennes, UMR 6118, Rennes, France — 3Institut de Mécanique des Fluides de Toulouse, UMR 5502, CNRS, University of Toulouse, Toulouse, France
Despite of the high dependency of brain cells function on the efficiency of blood transport throughout the micro-vasculature, only little is known about the physical processes that drive neural cell supply. Here, based on the statistical analysis of realistic blood flow computations in mouse brain micro-vascular networks, we develop a statistical framework relating the structure of micro-vascular networks to the observed blood flow and transport heterogeneities. In particular, this framework enables to investigate the detrimental consequences of the cerebral blood flow decrease, a key phenomenon at early stage of Alzheimer's disease. We notably predict, in agreement with simulations, that the anomalous nature of the transport induces a non-linear evolution of the size of the regions exhibiting a critical concentration in oxygen or in neuro-toxic metabolic wastes with the decrease of the cerebral blood flow, unraveling an additionnal mechanism contributing to Alzheimer's disease progress.