Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 13: Cytoskeleton
BP 13.10: Vortrag
Mittwoch, 7. September 2022, 12:15–12:30, H15
Processive molecular motors stimulate microtubule turnover — William Lecompte1, Sarah Triclin2, Laurent Blanchoin2,3, Manuel Théry2,3, and •Karin John1 — 1Univ. Grenoble-Alpes, CNRS, Laboratoire Interdisciplinaire de Physique, 38000 Grenoble, France. — 2Univ. Grenoble-Alpes, CEA, CNRS, INRA, Institute de Recherche Interdisciplinaire de Grenoble, Laboratoire de Physiologie Cellulaire & Végétale, CytoMorpho Lab, 38054 Grenoble, France — 3Univ. Paris Diderot, INSERM, CEA, Hôpital Saint Louis, Institut Universitaire d'Hematologie, UMRS1160, CytoMorpho Lab, 75010 Paris, France
Microtubules (MTs) and molecular motors are ubiquitous in eukaryotic cells and are vital for many key cellular functions (eg. chromosome segregation, intracellular protein transport). Recent experiments have shown that processive molecular motors may damage the underlying microtubule lattice yet a mechanistic model has remained elusive. Here we investigate theoretically how molecular motors collectively remodel the shaft lattice, as opposed to a vision, where a single motor damages the microtubule as a rare event. Our leading concept is, that the walk of molecular motors locally and transiently destabilizes the lattice and may facilitate the removal of tubulin dimers. This mechanism (i) accelerates fracture of MTs in the absence of free tubulin and (ii) stimulates localized free tubulin dimer incorporation. The model reveals that a small transient perturbation (a few kT with a lifetime of 0.1 s) induced by the motor's walk is sufficient to modify significantly the lattice dynamics.