Regensburg 2022 – scientific programme

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BP: Fachverband Biologische Physik

BP 19: Cell Mechanics 2

BP 19.2: Talk

Wednesday, September 7, 2022, 15:15–15:30, H16

Modeling Cell Shape and Forces on Structured Environments in Three Dimensions — •Rabea Link and Ulrich Sebastian Schwarz — Institute for Theoretical Physics, University Heidelberg, Germany

Micropatterns are a widely used tool to standardize the mechanical environment single cells or cell collectives experience in experiments. In recent years, microstructures manufactured with direct laser writing have tremendously increased the design possibilities of structured environments for cells. We model the shape, spreading dynamics and forces of a single cell with external adhesive cues using a three-dimensional compartmentalized Cellular Potts Model on 2D micropatterns and in 3D structured environments. This allows us to investigate the influence of the nucleus on the cell shape and spreading dynamics. In addition, we compare the cell shapes obtained by the Cellular Potts Model with the minimal energy shape of a surface under tension in the same mechanical environment and with experimental results.