Regensburg 2022 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 22: Migration and Multicellular Systems

BP 22.7: Vortrag

Donnerstag, 8. September 2022, 11:30–11:45, H15

Active cell mechanisms reveal rich tissue-wide structures and dynamics in simulations — •Maxime Hubert¹, Lovro Nuić², Kevin Höllring¹, and Ana-Sunčana Smith^1,2 — ¹PULS group, FAU Erlangen-Nürnberg, Erlangen, Germany — ²Group for Computational Life Sciences, Ruđer Bošković Institute, Zagreb, Croatia

Dissipative Particle Dynamics simulations provide a robust numerical platform of investigation to understand the dynamics of epithelial tissues. The technique allows to implement various properties at the cell level that can be related to tissue-wide structures and dynamics on various time scales, from hours to days in experiments. In this talk, we present our recent progresses in the field of epithelium numerical simulations by implementing different active ingredients that relate to the immediate neighbourhood of the cell within a tissue monolayer. We show, through comparisons with experiments performed with MDCK-II cells, that we are able to capture the formation of macroscopic compartments of the tissue, the complex relation between average cell velocity and cell density, and the rate of expansion of the tissue. These results highlight the importance of “nuclei”-based approaches along with “membrane”-based approaches in order to provide a complete numerical and mechanical perspective of epithelial tissues across various time- and length-scales.