Regensburg 2022 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 3: Cell Mechanics 1
BP 3.4: Vortrag
Montag, 5. September 2022, 10:30–10:45, H15
Mechanical Properties of the Premature Lung — •Jonas Naumann1, Nicklas Koppe1, Ulrich Herbert Thome2, Mandy Laube2, and Mareike Zink1 — 1Research Group Biotechnology and Biomedicine, Peter-Debye-Institute for Soft Matter Physics, Leipzig University, 04103 Leipzig, Germany — 2Center for Pediatric Research Leipzig, Department of Pediatrics, Division of Neonatology, Leipzig University, 04103 Leipzig, Germany
Even though mechanical ventilation is a life-saving therapy for premature infants suffering from respiratory distress syndrome, prolonged ventilation and related mechanical load may cause subsequent pulmonary diseases such as bronchopulmonary dysplasia. To study the effect of mechanical stress on the immature lung, premature rat lungs were subjected to rheology experiments in compression and tension at different velocities. Here, fetal lungs behaved significantly stiffer with increasing deformation velocities as also used during high-frequency ventilation. A higher Young's modulus of fetal rat lungs compared to adult controls clearly pointed towards altered tissue characteristics. Furthermore, influences of hydrostatic pressure differences on the electrophysiology of lung epithelial cells were studied with a pressure-adjustable Ussing chamber. We observed a strong impact of hydrostatic pressure on vectorial sodium transport, important for alveolar fluid clearance. These pressure-dependent cellular alterations might explain clinical observations of ventilation-induced side effects.