Regensburg 2022 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 7: Poster 1
BP 7.18: Poster
Montag, 5. September 2022, 18:00–20:00, P1
In Silico Tumor Invasion — •Eric Behle1, Julian Herold2, and Alexander Schug1 — 1JSC, Jülich Research Centre, Wilhelm-Johnen-Straße, 52428 Jülich, Germany — 2Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany
To this day, cancer remains an insufficiently understood disease plaguing humanity. In particular, the mechanisms driving tumor invasion still require extensive study. Current investigations address collective cellular behavior within tumors, which leads to solid or fluid tissue dynamics. Furthermore, the extracellular matrix (ECM) has come into focus as a driving force facilitating invasion. To complement the experimental studies, computational models are employed, and advances in computational power within HPC systems have enabled the simulation of macroscopic tissue arrangements. In line with this, we hereby present our work using Cells in Silico (CiS), a high performance framework for large-scale tissue simulation developed by us. Combining a cellular potts model and an agent-based layer, CiS is capable of simulating tissues composed of millions of cells, while accurately representing many physical and biological properties. We aim to parameterize CiS via a bottom-up approach, starting with experimental data from small systems. We focused our studies on tumor spheroids, spherical aggregates composed of thousands of individual cells, which are one of the main workhorses of tumor analysis. We investigated the invasion dynamics and their dependence on the ECM density, and further aim to apply our model to the realistic simulation of larger systems.