Regensburg 2022 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 7: Poster 1

BP 7.2: Poster

Montag, 5. September 2022, 18:00–20:00, P1

Transport in complex intracellular environments — •Mohammad Amin Eskandari, Bart Vos, Mattias Luber, and Timo Betz — Third Institute of Physics - Biophysics Georg August University Göttingen

Active transport is vital for targeted delivery of organelles, proteins and signaling molecules in eukaryotic cells and defects in active transport are linked to different diseases such as Alzheimer's disease. Kinesin and dynein are two motor proteins which are responsible to carry the cargoes along the microtubule filaments. Since the cytoplasm is a highly crowded environment, the motion of cargoes can be hindered by some sorts of obstacles and this brings us to the question how these motors can generate a processive motion in such an environment to bypass the roadblocks. In this project, we aim to investigate the possible mechanisms that kinesin and dynein can use to overcome the obstacles.