Regensburg 2022 – scientific programme
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BP: Fachverband Biologische Physik
BP 7: Poster 1
BP 7.29: Poster
Monday, September 5, 2022, 18:00–20:00, P1
Microscale resonators for microfluidic based Nuclear Magnetic Resonance spectroscopy — •Alaleh Mirhajivarzaneh1, Piotr Lepucki1, Adam P. Dioguardi1, Aleksandr I. Egunov1, Marco Rosenkranz1, Renato Huber1, Daniil Karnaushenko1, Dmitry D. Karnaushenko1, Oliver G. Schmidt3,4, Bernd Büchner1,2, and Hans-Joachim Grafe1 — 1Leibniz Institute for Solid State and Materials Research (IFW) Dresden — 2Dresden University of Technology, Faculty of Physics — 3Research Center for Materials, Architectures and Integration of Nanomembranes (MAIN), Chemnitz — 4Chemnitz University of Technology, Material Systems for Nanoelectronics
Over the past few decades efforts to miniaturize Nuclear Magnetic Resonance (NMR) spectroscopy have resulted in the down-scaling of the core of an NMR system to microscale detectors. This achievement has unfolded a new era of NMR spectroscopy, with applications particularly in biological studies, where the sample size can scale down to micro- or nanoliters (nL), typical of microorganism and cell cultures. Our novel microcoil is a 3D microscale resonator with an integrated microfluidic system that offers high sensitivity and resolution (8ppb) for analyte volumes as small as 1.5nL, one of the smallest reported detection volumes in the field of NMR spectroscopy. Additionally, the integrated microfluidic system optimizes the filling factor of the device to reach almost 100%. The rolled-up microcoil can potentially be employed for high-resolution micro-NMR analysis of biological samples.