Regensburg 2022 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 12: Poster 1
CPP 12.9: Poster
Montag, 5. September 2022, 18:00–20:00, P1
Studying the nanomechanical properties of functional organic and biologic macromolecules — Ilka M. Hermes1, Andrea Cerrata2, Vladimir Korolkov2, and •Alexander Klasen2 — 1Leibniz-Institut für Polymerforschung Dresden e.V., Dresden, Germany — 2Park Systems Europe GmbH, Mannheim, Germany
As the functionality of organic and biologic macromolecules is often determined by their nanomechanical properties, visualizing the distribution of mechanical properties on the nanoscale provides crucial insights for soft matter research. [1,2] Here, we present a study on structural and nanomechanical properties of functional organic and biologic macromolecules in different environments as well as under external stimuli, such as temperature, ion concentration and pH. Force-distance measurements with atomic force microscopy (AFM) resolve adhesion and elasticity by pressing a nanometer-sized tip on the end of a cantilever onto the surface. However, the correlation of mechanical data from force-distance measurements to the local sample morphology additionally requires topographic sample information. PinPointTM nanomechanical imaging simultaneously acquires topographic and force-distance data within short amounts of time and is therefore ideally suited to investigate organic and biologic macromolecules.
1. S. Perni et al., Langmuir 32, 7965-7974 (2016).
2. E. E. Bastounis et al., Mol. Biol. Cell 29, 1571-1589 (2018).