Regensburg 2022 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 44: Focus Session: Soft Matter and Nanocomposites: New Opportunities with Advanced Neutron Sources 2

CPP 44.1: Hauptvortrag

Freitag, 9. September 2022, 09:30–10:00, H38

Connecting dynamics and phase behavior of proteins: The neutron perspective — •Frank Schreiber — Universität Tübingen, Germany

We discuss the combination of various neutron scattering techniques to shed light on the dynamics of proteins in aqueous solution. This includes several processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. In particular, we connect it to the overall phase behavior in terms of clustering, crowding, crystallization, and phase separation [1], employing a combination of elastic, quasi-elastic, and inelastic scattering [2] as well as complementary techniques, such as X-ray photon correlation spectroscopy (XPCS) and simulations [3]. Finally, we comment on future perspectives with advanced neutron sources. Invaluable contributions by numerous collaborators are gratefully acknowledged.

[1] M. Grimaldo et al., JPCL, 10, 1709 (2019) [2] M. Grimaldo et al., Quarterly Reviews of Biophysics, 52, e7 (2019) [3] A. Girelli et al., Phys. Rev. Lett. 126 (2021) 138004