Regensburg 2022 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 39: Pattern Formation and Reaction-Diffusion Systems
DY 39.5: Vortrag
Donnerstag, 8. September 2022, 11:15–11:30, H19
Control of spatiotemporal chaos in 2D excitable media using non-equidistant pulse sequences — Marcel Aron1,2,3, Thomas Lilienkamp2,4, Stefan Luther1,2,3,5, and •Ulrich Parlitz2,3,5 — 1Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany — 2Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 3Institute for the Dynamics of Complex Systems, Georg-August-Universität Göttingen, Göttingen, Germany — 4Computational Physics in den Life Sciences, Technische Hochschule Nürnberg, Nürnberg, Germany — 5German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen, Germany
The emergence of spatiotemporal chaos (i.e. fibrillation) in the cardiac muscle (an excitable medium) leads to loss of pumping function and sudden cardiac death. Clinically, such episodes are treated with high-energy electric shocks to control (terminate) the chaotic dynamics and restore a regular heart rhythm. However, high shock energies result in increased risk of tissue damage or worsening the overall prognosis. This motivates the search for alternatives, including periodic sequences of low-energy electric pulses of constant field strength, which has seen success in pre-clinical trials on pig hearts.
Here we show that non-uniform pulse energies and time intervals can be used to further optimise the control of spatiotemporal chaos in 2D simulations of homogeneous cardiac tissue. We use a simplified shock-application model and define control-performance metrics to employ a genetic algorithm in the search for more efficient control approaches.