Regensburg 2022 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 39: Pattern Formation and Reaction-Diffusion Systems

DY 39.8: Vortrag

Donnerstag, 8. September 2022, 12:00–12:15, H19

Robustness of in vivo Min patterns underlines complex protein interaction motives — •Henrik Weyer, Laeschkir Würthner, and Erwin Frey — Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universität München, Theresienstraße 37, D-80333 München, Germany

The Min protein system organizes the symmetric cell division of E. coli bacteria: Two proteins, MinD and MinE, undergo pole-to-pole oscillations via a reaction–diffusion mechanism, and guide the cell-division machinery towards midcell. In elongated, filamentous cells the pole-to-pole oscillations transition into a standing-wave pattern forming several stripes along the cell. We show that modeling of the latent MinE state, which allows for Min pattern formation over a large range of MinE densities, suppresses standing-wave patterns. This effect is explained to demonstrate a generic mechanism that latent states form a homogeneous reservoir in reaction–diffusion systems. We reason that the MinE–MinD interaction cannot be described as a single hydrolysis step, and that MinE plays a more complex role in the Min protein network, a finding supported by recent experimental evidence.