Regensburg 2022 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 42: Statistical Physics of Biological Systems 2 (joint session BP/DY)
DY 42.1: Vortrag
Donnerstag, 8. September 2022, 15:00–15:15, H16
Sensing and making sense of fluctuating cellular states — •Felix J. Meigel1, Lina Hellwig2, Philipp Mergenthaler2, and Steffen Rulands1,3 — 1Max Planck Institute for Physics of Complex Systems, Dresden — 2Neurology Department, Charité University Medicine Berlin — 3Center for Systems Biology Dresden
The self-organisation of cells into complex tissue relies on the tight regulation of cellular responses to fluctuating cues. Typically, the regulation of cell decisions is attributed to pathways controlling the concentration of molecular species in response to intrinsic or extrinsic signal. Here, by contrast, we show in the paradigmatic example of cell death that cells manipulate how fluctuations propagate across spatial scales to regulate cellular behavior. Specifically, we find that the feedback between molecular and mesoscopic organelle fluctuations gives rise to a quasi-particle degree of freedom whose intriguing kinetic properties construct a kinetic low-pass filter of time-dependent concentrations of signaling molecules. We show that the collective dynamics of the quasi-particle degree of freedom exhibits different kinetics on different temporal scales. This allows cells to distinguish between fast fluctuations and slow, biologically relevant changes in environmental signals. We demonstrate an order of magnitude effect of this phenomenon on the quality of the cell death decision and validate our predictions experimentally by dynamically perturbing the intrinsic apoptosis pathway. Our work reveals a new mechanism of cell fate decision making.