Regensburg 2022 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 45: Poster Session: Nonlinear Dynamics, Pattern Formation, Data Analytics and Machine Learning

DY 45.5: Poster

Donnerstag, 8. September 2022, 15:00–18:00, P2

Synchronizing Cells Based on Local Interactions — •Stephan Kremser, Mareike Bojer, and Ulrich Gerland — Physics Department, Technical University of Munich

Tissue-wide temporal synchronization of cellular processes is a desirable property for many systems in synthetic and developmental biology. Here, we look at a setting were cells have only limited information about the behavior of neighboring cells, receiving new information only after these neighbors change their internal state. Under these assumptions, we ask if global synchronization can be reached based on local (e.g. direct contact) interactions. We develop a conceptual model of the synchronization process and explore it computationally for different dimensions and interaction network topologies of the tissue. We show that temporal corrections to cellular processes based on magnitude ('proportional feedback control') or sign ('on-off feedback control') of local time differences are enough to conserve local synchronization and bound global asynchrony by a constant independent of time for a long period of time. This allows us to establish a link to the physics of growing surfaces and to investigate the interplay of patterning and synchronization dynamics.