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MA: Fachverband Magnetismus

MA 35: Poster 2

MA 35.61: Poster

Donnerstag, 8. September 2022, 16:00–18:00, P4

Fe3N nanoparticles as alternative material for magnetic fluid hyperthermia — •Yevhen Ablets, Imants Dirba, and Oliver Gutfleisch — Technical University of Darmstadt, Darmstadt, Germany

Magnetic fluid hyperthermia (MFH) is one of the modern individual and adjuvant methods for cancer treatment. Usually, iron oxide nanoparticles (IONP) are used for this purpose due to their chemical stability, non-toxicity, well-established and cost-effective production, well-known metabolism of iron in the human body. However, the heating performance of IONP is limited due to moderate values of saturation magnetization and magnetocrystalline anisotropy. Using particles with enhanced magnetic properties will enable more effective tumor treatment, and within AC magnetic field amplitude (H) and frequency (f) conditions of the so-called Brezovich-Atkinson criteria (H*f = 5x10^8 A/m*s), which leads to less discomfort for the patients.

In this work, a new synthesis method of crystalline Fe3N nanoparticles is demonstrated. Metal-organic compound iron pentacarbonyl is thermally decomposed in the presence of polyisobutylene succinimide under continuous ammonia flow. Varying gas flow concentrations and type of surfactant (oleic acid, oleylamine) Fe3O4 and Fe homogeneous spherical particles were obtained with an average diameter of 14 nm. Fe3N particles show better magnetic properties and heating performance than Fe3O4 and better chemical stability compared to Fe particles. First stage biocompatible studies are ongoing.