Regensburg 2022 – wissenschaftliches Programm

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PRV: Preisträgervorträge

PRV III

PRV III: Preisträgervortrag

Mittwoch, 7. September 2022, 13:15–13:45, H1

Learning the stochastic dynamics of living systems across scales: from single cells to tissues — •David Brückner — Institute of Science and Technology, Am Campus 1, 3400 Klosterneuburg, Austria — Laureate of the Gustav-Hertz-Prize 2022

Many biological phenomena, including embryo development, immune response, and cancer, rely on the coordinated movement of cells in complex environments. In all these processes, cells face a dual physical challenge: they navigate confining extra-cellular environments, in which they squeeze through thin constrictions; and they communicate with close-by cells to organize their collective behaviour. The motion of cells is powered by a complex machinery whose molecular basis is increasingly well understood. However, a quantitative understanding of the functional cell behaviours that emerge at the cellular scale remains elusive. This raises a central question: are there simple dynamical 'laws' that describe the dynamics of confined cell migration and cell-cell interactions? In this talk, I will discuss how we can use stochastic inference methods to learn the dynamics of migrating cells directly from observed experimental trajectories. I will show how these approaches give insight into the non-linear dynamics governing confined single cell migration, the pair-wise collisions of cancerous and healthy cell types, as well as collective cell migration at the tissue level.