SAMOP 2023 – scientific programme

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Q: Fachverband Quantenoptik und Photonik

Q 14: Quantum Technologies: Color Centers I (joint session Q/A/QI)

Q 14.1: Talk

Monday, March 6, 2023, 17:00–17:15, F342

NMR-fingerprinting of biomolecules on the picoliter level — •Nico Striegler, Thomas Unden, Jochen Scharpf, Stephan Knecht, Christophoros Vassiliou, Jochen Scheuer, Michael Keim, John Blanchard, Martin Gierse, Mohammad Usman Qureshi, Ilai Schwartz, and Philipp Neumann — NVision Imaging Technologies GmbH

A standard method for diagnostics and analytics is nuclear magnetic resonance (NMR). Conventional NMR only function well for large enough samples and is inherently limited by the low thermal spin polarisation. The combination of nuclear spin hyperpolarisation with a microscale quantum sensor enables study of metabolism on the single-cell level. This can be used for evaluating the treatment effectiveness from tumor biopsies using only a few cells. In this study the combination of a Nitrogen-Vacancy-based quantum sensor and a hyperpolarized Fumarate solution enables heteronuclear magnetic resonance spectroscopy of liqudis in picoliter volumes. The NMR probe is based on an ensemble of negatively charged Nitrogen-Vacancy (NV) centers in a ten micrometer thick diamond layer. Hyperpolarization of the solution is based on parahydrogen induced polarization (PHIP) methods, which is done in house and then transferred to the detection volume of the quantum sensor. Microwave pulse sequences brings the NV electron spins into adjustable frequencies for detection of AC magnetic fields generated by the nuclear spins of interest.