SKM 2023 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 1: Membranes, Vesicles, Synthetic Cells
BP 1.11: Vortrag
Montag, 27. März 2023, 12:30–12:45, BAR Schö
X-ray studies of bidirectional switching in phospholipid membranes containing photoswitchable glycolipids — •Svenja C. Hövelmann1,2,3, Jonas E. Warias1, Rajendra P. Giri1, Jule Kuhn1, Karin Hansen1, Lukas Petersdorf1, Nicolas Hayen1, Philipp Jordt1, Andrea Sartori1, Chen Shen3, Franziska Reise4, Olaf M. Magnussen1, Thisbe K. Lindhorst4, and Bridget M. Murphy1,3 — 1Institute of Experimental and Applied Physics, Kiel, Germany — 2Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany — 3Ruprecht Haensel Laboratory, Kiel, Germany — 4Otto Diels Institute of Organic Chemistry, Kiel, Germany
Lipid molecules not only play an essential role in the structure and geometry in biomembranes but also in the functionality and self-assembly of membrane proteins and channels. Their dynamic is under intense investigation owing to their applications in biosensor engineering and drug delivery. To understand the interaction between lipid and functional molecules, we investigate photoswitchable glycoconjugates embedded in a 1,2-dipalmitoyl-phosphatidylcholine (DPPC) model systems in the form of Langmuir films and vesicles. The glycoconjugates change reversibly between their trans- and cis-conformation by illumination with visible and UV light inducing a reversible change in the surrounding molecular arrangement. These structural changes, their evolution and time scales are characterised with multiple measurement techniques including X-ray scattering. Studies performed on mixed monolayers and vesicles with varying glycoconjugates identify bidirectional switching in the in DPPC monolayers.