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SKM 2023 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 1: Membranes, Vesicles, Synthetic Cells

BP 1.5: Vortrag

Montag, 27. März 2023, 10:30–10:45, BAR Schö

Predicting membrane turnover during cytokinesis — •Felix Frey1 and Timon Idema21Institute of Science and Technology Austria, Klosterneuburg, Austria — 2Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands

When animal cells divide, they split into two equal parts. Since the volume of the cell is typically conserved during cell division, the projected area of the cell membrane has to increase to allow for the change of shape. The membrane area is controlled by exocytosis, resulting in an increase in membrane area and its counterpart endocytosis, resulting in a decrease in membrane area. However, it is unclear how exo- and endocytosis need to adapt to enable successful division. To address this question, we developed a kinetic model in which membrane gain and loss depend on membrane curvature and tension [1]. We apply this model to a series of calculated vesicle shapes, which we take as a proxy for the shape of dividing cells. We find that the ratio of membrane gain and loss changes non-monotonically during cytokinesis due to the complex interplay between membrane area and shape. Our results suggest that controlling membrane turnover is critical for the successful division of both biological and artificial cells. [1] Felix Frey and Timon Idema, Phys. Rev. E 106, 024401 (2022).

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