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BP: Fachverband Biologische Physik

BP 1: Membranes, Vesicles, Synthetic Cells

BP 1.8: Vortrag

Montag, 27. März 2023, 11:45–12:00, BAR Schö

Entry of Microparticles into Giant Lipid Vesicles Induced by Optical Force — •Fessler Florent, Sharma Vaibhav, Muller Pierre, Thalmann Fabrice, Marques Carlos, and Stocco Antonio — Institut Charles Sadron, Strasbourg, France

Interactions between micro- or nano-sized objects and lipid membranes are crucial in many processes such as entry of viruses in host cells, microplastics pollution, drug delivery or biomedical imaging. Here, we investigated the physical principles of particle crossing of lipid membranes using microparticles and giant unilamellar vesicles (GUVs) in the absence of strong irreversible binding and for low membrane tensions. In these conditions, we observed that organic as well as inorganic particles can always penetrate inside GUVs provided that an external picoNewton force is applied. In the limit of a vanishing particle-membrane affinity, we pointed out the role of membrane area reservoirs and showed that a force barrier minimum exists when the particle size is comparable to the bendocapillary length.